Effect of different exposure times on physicochemical, mechanical and biological properties of PGS scaffolds treated with plasma of iodine-doped polypyrrole

• Published in: Journal of biomaterials applications Vol. 35; no. 4-5; p. 485
• Main Authors: Martín-Pat, Gaspar Eduardo, Rodriguez-Fuentes, Nayeli, Cervantes-Uc, J Manuel, Rosales-Ibáñez, Raúl, Carrillo-Escalante, Hugo Joel, Ku-Gonzalez, Angela F, Avila-Ortega, Alejandro, Hernandez-Sanchez, Fernando
• Format: Journal Article
• Language: English
• Published: England 01.10.2020
• Subjects: polypyrrole; poly (glycerol sebacate); cellular viability; cytotoxicity assa; iodine; Scaffold; plasma
• ISSN: 1530-8022
• DOI: 10.1177/0885328220941466

Polyglycerol sebacate (PGS) scaffolds obtained using a leaching technique were modified with iodine-doped polypyrrole (PPy-I) in a plasma reactor in order to study the effect of exposure time on the cell viability of hDPSCs. SEM analysis showed the formation and growth of PPy-I particles as the exposure time was increased, while FTIR and XPS analysis revealed the presence of -NH- and N+ groups in the chemical composition of the surfaces, relating to the increase in the amount of PPY-I particles. The water contact angle measurements showed an increase in the scaffold's hydrophilicity with greater exposure times which was also attributed to the rising of PPy-I particles. It was also observed that PPy-I promotes the rigidity of the treated PGS scaffolds. when in direct contact with treated PGS scaffolds, cell viability improved with respect to non-treated scaffolds, however only at shorter time exposures. Extracts of plasma-treated PGS scaffolds showed high cytotoxicity as the time exposure to plasma treatment was increased.