Serologic Assays Specific to Immunoglobulin M Antibodies against Hepatitis E Virus: Pangenotypic Evaluation of Performances

Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated. Serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well...

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Published inClinical infectious diseases Vol. 51; no. 3; pp. e24 - e27
Main Authors Drobeniuc, Jan, Meng, Jihong, Reuter, Gábor, Greene-Montfort, Tracy, Khudyakova, Natasha, Dimitrova, Zoya, Kamili, Saleem, Teo, Chong-Gee
Format Journal Article
LanguageEnglish
Published United States The University of Chicago Press 01.08.2010
Subjects
Hepatitis Antibodies - blood
Hepatitis E - diagnosis
Hepatitis E virus - classification
Hepatitis E virus - immunology
Humans
Immunoglobulin M - blood
Sensitivity and Specificity
Serologic Tests
Virology - methods
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Summary:Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated. Serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreement varied widely. Analytical sensitivity limits also were determined and were found to be particularly disparate.
Bibliography:ark:/67375/HXZ-26PWSP20-9
istex:118D3070229C6FCA145D3CF28B04FFE5974083AF
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1058-4838
1537-6591
DOI:10.1086/654801