Stereochemical control of asymmetric hydrogen transfer employing five different kinds of fungi in anhydrous hexane

Nonracemic 1-phenylethyl alcohol of R and S configuration and of high enantiomeric purity was obtained by bioreduction of acetophenone in nonaqueous environment—anhydrous hexane. Immobilized cells of five different kinds of microorganisms were tested as biocatalysts, namely: Rhodotorula rubra, Rhodo...

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Published inEnzyme and microbial technology Vol. 34; no. 6; pp. 578 - 582
Main Authors Żymańczyk-Duda, Ewa, Brzezińska-Rodak, Małgorzata, Lejczak, Barbara
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.05.2004
Elsevier Science
Subjects
Biological and medical sciences
Bioreduction
Biotechnology
Cladosporium
Fundamental and applied biological sciences. Psychology
Fungi
Rhodotorula glutinis
Rhodotorula rubra
Stereochemical control
Verticillium
Fungi
Bioreduction
Stereochemical control
Hydrogen transfer
Asymmetric reaction
Hexane
Stereochemistry
Thallophyta
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Summary:Nonracemic 1-phenylethyl alcohol of R and S configuration and of high enantiomeric purity was obtained by bioreduction of acetophenone in nonaqueous environment—anhydrous hexane. Immobilized cells of five different kinds of microorganisms were tested as biocatalysts, namely: Rhodotorula rubra, Rhodotorula glutinis, Cladosporium sp., Verticillium sp. and baker’s yeast. The effect of parameters such as the addition of chemical compounds influencing the stereoselectivity of bioreduction and the mode of biocatalyst pretreatment (permeabilization or cultivation under anaerobic conditions) has been investigated.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0141-0229
1879-0909
DOI:10.1016/j.enzmictec.2004.01.009