MicroRNAs as important regulators of the NLRP3 inflammasome

• Published in: Progress in biophysics and molecular biology Vol. 150; pp. 50 - 61
• Main Authors: Zamani, Parvin, Oskuee, Reza Kazemi, Atkin, Stephen L., Navashenaq, Jamshid Gholizadeh, Sahebkar, Amirhossein
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2020
• Subjects: Animals; Base Sequence; Caspase 1 - metabolism; Caspase-1; Gene Expression Regulation; Humans; IL-18; IL-1β; Inflammasomes - genetics; Inflammasomes - metabolism; Inflammation; Inflammation - metabolism; Interleukin-18 - metabolism; Interleukin-1beta - metabolism; MicroRNA; MicroRNAs - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3 inflammasomes; Nucleic Acid Conformation; RNA Processing, Post-Transcriptional; RNA, Messenger - metabolism; Signal Transduction; Inflammation; MicroRNA; NLRP3 inflammasomes; IL-1β; IL-18; Caspase-1
• ISSN: 0079-6107; 1873-1732; 1873-1732
• DOI: 10.1016/j.pbiomolbio.2019.05.004

Inflammasomes are a group of cytosolic multi-protein signaling complexes that regulate maturation of the interleukin (IL)-1 family cytokines IL-1β and IL-18 through activation of inflammatory caspase-1. The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome is the best characterized and consists of several key components that are assembled and activated in response to different endogenous and exogenous signals. The NLRP3 inflammasome is common to a number of human inflammatory diseases and its targeting may lead to novel anti-inflammatory therapy. NLRP3 inflammasome activation is tightly regulated by different mechanisms especially post-transcriptional modulation via microRNAs (miRNA). MicroRNAs are small endogenous noncoding RNAs that are 21–23 nucleotides in length and control the expression of various genes through binding to the 3′-untranslated regions of the respective mRNA and subsequent post-transcriptional regulation. MicroRNAs have recently been recognized as crucial regulators of the NLRP3 inflammasome. In this review, we summarize the current understanding of the role of miRNAs in the regulation of NLRP3 inflammasome complexes and their impact on the pathogenesis of inflammatory disease processes.