2-methoxyethylacrylate modified polyurethane membrane and its blood compatibility

• Published in: Progress in biophysics and molecular biology Vol. 148; pp. 39 - 46
• Main Authors: Tian, Xin, Qiu, Yun-Ren
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2019
• Subjects: 2-methoxyethlacrylate; Acrylates - chemistry; Adsorption; Adult; Animals; Biocompatibility; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Blood compatibility; Humans; Hydrophilic membrane; Male; Materials Testing; Membranes, Artificial; Platelet Adhesiveness - drug effects; Polyurethane; Polyurethanes - chemistry; Polyurethanes - pharmacology; Serum Albumin, Bovine - chemistry; Surface Properties; Hydrophilic membrane; Blood compatibility; Biocompatibility; 2-methoxyethlacrylate; Polyurethane
• ISSN: 0079-6107; 1873-1732
• DOI: 10.1016/j.pbiomolbio.2017.10.003

Hydrophilic material 2-methoxyethylacrylate (MEA) was grafted onto polyurethane (PU) membrane via Michael addition reaction. Fourier transform infrared spectroscope (FTIR) and X-ray photoelectron spectroscopy (XPS) characterizations of the modified membrane proved that MEA was successfully grafted onto PU membrane surface. The water contact angle of the modified PU membrane decreased from 86° to 48° compared with unmodified PU membrane, which means that the hydrophilicity of the modified membrane was greatly improved. A series of blood compatibility tests including bovine serum protein adsorption, platelet adhesion, hemolysis assay, plasma recalacification time, prothrombin time (PT), partial thromboplastin time (APTT) and thrombin time (TT) were carried out on PU membrane and the modified PU membrane with highest grafted density of MEA. The combined results indicate that MEA plays an important role in improving the blood compatibility of PU membrane. [Display omitted] •The PU-g-PMEA membrane was successfully prepared through a three-step reaction.•2-methoxyethylacrylate was grafted onto PU membrane surface via Michael addition reaction.•The modified PU-g-PMEA membrane has better blood compatibility than pristine PU membrane.