Social support and fear-inhibition: an examination of underlying neural mechanisms

• Published in: Social cognitive and affective neuroscience Vol. 19; no. 1
• Main Authors: Hornstein, E.A, Leschak, C J, Parrish, M H, Byrne-Haltom, K E, Fanselow, M S, Craske, M G, Eisenberger, N I
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 22.01.2024
• Subjects: Amygdala - diagnostic imaging; Amygdala - physiology; Extinction, Psychological - physiology; Fear - physiology; Humans; Magnetic Resonance Imaging - methods; Original Research – Neuroscience; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiology; Social Support; social support; prepared fear suppressors; retardation-of-acquisition; ventromedial prefrontal cortex; fear-inhibition
• ISSN: 1749-5016; 1749-5024
• DOI: 10.1093/scan/nsae002

Abstract Recent work has demonstrated that reminders of those we are closest to have a unique combination of effects on fear learning and represent a new category of fear inhibitors, termed prepared fear suppressors. Notably, social-support-figure images have been shown to resist becoming associated with fear, suppress conditional-fear-responding and lead to long-term fear reduction. Due to the novelty of this category, understanding the underlying neural mechanisms that support these unique abilities of social-support-reminders has yet to be investigated. Here, we examined the neural correlates that enable social-support-reminders to resist becoming associated with fear during a retardation-of-acquisition test. We found that social-support-figure-images (vs stranger-images) were less readily associated with fear, replicating prior work, and that this effect was associated with decreased amygdala activity and increased ventromedial prefrontal cortex (VMPFC) activity for social-support-figure-images (vs stranger-images), suggesting that social-support-engagement of the VMPFC and consequent inhibition of the amygdala may contribute to unique their inhibitory effects. Connectivity analyses supported this interpretation, showing greater connectivity between the VMPFC and left amygdala for social-support-figure-images (vs stranger-images).