Factor X Deficiency: A Rare Cause of Puberty Menorrhagia

• Published in: Indian journal of pediatrics Vol. 80; no. 7; pp. 607 - 608
• Main Authors: Singh, Virender, Kakkar, Tania, Digra, Sanjeev K., Kakkar, Manisha
• Format: Journal Article
• Language: English
• Published: India Springer India 01.07.2013; Springer
• Subjects: Adolescent; Biological and medical sciences; Blood Transfusion; Clinical Brief; Consanguinity; Factor X Deficiency - diagnosis; Factor X Deficiency - therapy; Female; Female genital diseases; General aspects; Gynecology; Gynecology. Andrology. Obstetrics; Hematologic and hematopoietic diseases; Humans; Medical sciences; Medicine; Medicine & Public Health; Menarche; Menorrhagia - etiology; Non tumoral diseases; Pediatrics; Platelet diseases and coagulopathies; Factor X deficiency; Puberty menorrhagia; Pediatrics; Menstruation disorders; Uterine diseases; Tropical medicine; Hemopathy; Hemorrhage; Coagulopathy; Menorrhagia; Genetic disease; Female genital diseases
• ISSN: 0019-5456; 0973-7693
• DOI: 10.1007/s12098-012-0796-7

Factor X deficiency is an extremely rare coagulation defect inherited as an autosomal recessive disorder with variable bleeding manifestations. The authors report case of a 16 y-old girl born from a consanguineous marriage who presented with excessive bleeding at the start of menarche. Investigations revealed severe anemia, prolongation of both prothrombin time and activated partial thromboplastin time and moderate deficiency of factor X (1 %). She was given multiple transfusions including packed cells and fresh frozen plasma and was advised to remain under regular follow up.