Adjuvant Chemotherapy in Elderly Patients with Early-stage Non-small Cell Lung Cancer

• Published in: Bezmialem science Vol. 7; no. 4; pp. 265 - 270
• Main Authors: KEFELİ, Umut, KAYMAZ, Samet, AYDIN, Dinçer, IŞIK, Deniz, ÇABUK, Devrim, SONKAYA, Alper, AÇIKGÖZ, Özgür, IŞIK, Ulaş, ÖZDEN, Ercan, UYGUN, Kazım
• Format: Journal Article
• Language: English
• Published: Istanbul Galenos Yayınevi 01.10.2019; Galenos Publishing House
• Subjects: adjuvant; Age; Cancer therapies; Chemotherapy; elderly; Lung cancer; Multivariate analysis; non-small cell lung cancer; Patients; Surgery; Tıp; Tumors; İstanbul; Türkiye; United States > US; non-small cell lung cancer; elderly; Adjuvant
• ISSN: 2148-2373; 2148-2373
• DOI: 10.14235/bas.galenos.2018.2631

Objective: Early-stage non-small cell lung cancer (NSCLC) constitutes approximately 25-30% of newly diagnosed lung cancers. Elderly patients with NSCLC have generallly been underrepresented in clinical studies. We explored adjuvant chemotherapy results in patients ≥65 years with early-stage NSCLC. Methods: The medical records of 111 elderly patients with early-stage NSCLC were reviewed retrospectively. Collected data included demographic information, clinical assessments and information on treatment. Survival was estimated using the Kaplan-Meier method and prognostic factors were evaluated with log-rank and Cox regression tests. Results: The median disease-free survival (DFS) was 22.6 months. In univariate analysis, significant association between stage, performance score (PS), adjuvant chemotherapy and DFS was detected (p<0.05). Stage, PS and adjuvant chemotherapy were found to have significant effects on overall survival (OS) (p<0.05). The median survival for the entire group was 41.6 months. Multivariate analysis showed that stage, PS and adjuvant chemotherapy affected both DFS and OS. Conclusion: Survival of elderly patients with early-stage NSCLC was significantly influenced by stage, PS and adjuvant chemotherapy. These factors, rather than age, should be considered in the treatment planning for elderly patients with NSCLC.