In Vitro Cytotoxic and Anti-inflammatory Activities of Tanacetum argenteum (Lam.) Willd. subsp. argenteum Extract

• Published in: Turkish journal of pharmaceutical sciences Vol. 14; no. 3; pp. 231 - 236
• Main Authors: Albayrak, Gökay, Nalbantsoy, Ayşe, Baykan, Şüra
• Format: Journal Article
• Language: English
• Published: Turkey Türk Eczacılar Birliği 01.12.2017; Galenos Publishing
• Subjects: Eczacılık; Original; Sağlık Hizmetleri; Tıp; Ankara; Türkiye; anti-inflammatory; NF-κB; iNOS; Tanacetum argenteum subsp. argenteum; MTT; cytotoxicity; sitotoksisite; anti-inflamatuvar
• ISSN: 1304-530X; 2148-6247
• DOI: 10.4274/tjps.42714

The objective of this study was to examine the anti-inflammatory and cytotoxic potential of n-hexane, ethyl acetate, and methanolic extracts of subsp. . L. is the third largest genus of family and is represented by 60 taxa in Turkish flora. Sesquiterpene lactones and pyrethrins are the main chemical groups of the genus. subsp. is an endemic taxa that is distributed in the Central and South Anatolia. anti-inflammatory activity was assayed using iNOS and NF-κB inhibition tests on RAW264.7 and HeLa cells. The cytotoxic activities were tested against ten cell lines using MTT assays. As a result, the n-hexane extract was found more active than the positive control parthenolide in iNOS test (IC : 0.627±0.16 μg/mL) and cytotoxic experiments against PC3 and MPANC-96 cell lines (IC : 2.85±0.51 μg/mL and 5.35±1.24 μg/mL, respectively).