Evaluation of Physical and Biological Properties of Polyvinyl Alcohol/Chitosan Blend Films

Polyvinyl alcohol/chitosan (PVA/Cs) blend films with various compositions were prepared using glutaraldehyde (GA) as a crosslinker. The hydrophilicity and swelling behavior of the PVA/Cs films were assessed, and the biological properties of the PVA/Cs films, including cell culture in the extract, ce...

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Bibliographic Details
Published inJournal of macromolecular science. Physics Vol. 51; no. 9; pp. 1705 - 1714
Main Authors He, Zeqiang, Xiong, Lizhi
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Taylor & Francis Group 01.09.2012
Taylor & Francis
Subjects
Applied sciences
biological properties
chitosan
Exact sciences and technology
Natural polymers
Organic polymers
Physicochemistry of polymers
poly(vinyl alcohol)
Properties and characterization
Solution and gel properties
Starch and polysaccharides
swelling behavior
wettability
Biological properties
Hemolysis
swelling behavior
Swelling
Toxicity
poly(vinyl alcohol)
Cytotoxicity
Composition effect
Experimental study
Colloidal gel
Polyvinylalcohol
In vivo
Wettability
Animal
Morphology
Surface properties
Oside polymer
Biocompatibility
Chitosan
Fibroblast
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Summary:Polyvinyl alcohol/chitosan (PVA/Cs) blend films with various compositions were prepared using glutaraldehyde (GA) as a crosslinker. The hydrophilicity and swelling behavior of the PVA/Cs films were assessed, and the biological properties of the PVA/Cs films, including cell culture in the extract, cell cytotoxicity, and hemolytic and acute systemic toxicity tests were also investigated. The results showed that all composite films were hydrophilic materials with water contact angles changing from 45.3 ± 1.1° to 63.2 ± 1.8° when PVA content was varied from 100 to 0 wt%. The PVA/Cs films showed a significant reduction in swelling behavior as the chitosan content increased. Fibroblasts grown in PVA/Cs extract showed similar appearance with the cells cultured in the negative control medium, and the extract solution of PVA/Cs had no obvious cytotoxic effect. The hemolytic test suggested that the PVA/Cs, with a hemolytic index of 0.91%, did not have an obvious hemolytic reaction. There was no toxicosis or death observed in the acute systemic toxicity test. The results suggest that the complex of PVA and chitosan is a promising candidate biomaterial for tissue engineering.
ISSN:0022-2348
1525-609X
DOI:10.1080/00222348.2012.657584