Characteristics of gastric cancer around the world

• Published in: Critical reviews in oncology/hematology Vol. 181; p. 103841
• Main Authors: López, María J., Carbajal, Junior, Alfaro, Alejandro L., Saravia, Luis G., Zanabria, Daniel, Araujo, Jhajaira M., Quispe, Lidia, Zevallos, Alejandra, Buleje, José L., Cho, Cristina Eunbee, Sarmiento, Marisol, Pinto, Joseph A., Fajardo, Williams
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2023
• Subjects: Africa; Epidemiology; Europe - epidemiology; Female; Gastric cancer; Histology; Humans; Latin America - epidemiology; Male; Mutation; Risk Factors; Stomach Neoplasms - diagnosis; Stomach Neoplasms - epidemiology; Stomach Neoplasms - genetics; Europe; Africa; Latin America; Histology; Mutation; Gastric cancer; Epidemiology; Risk factors
• ISSN: 1040-8428; 1879-0461
• DOI: 10.1016/j.critrevonc.2022.103841

Gastric cancer is one of the most important malignancies in the world due to the high burden of disease and lethality. In this work, we compared the main characteristics of gastric cancer between different regions of the world. We reviewed public repositories to retrieve epidemiological, molecular, clinicopathological, and risk factor data. Eastern Asia presents the highest incidence of gastric cancer, followed by eastern and central Europe. Intestinal histology was more frequent in Caucasians, while gastric tumors located in the cardias were less frequent in Africa and Latin America. TP53, LRP1B, and ARID1A are consistently the most frequently altered genes in all population groups. Gastric cancer is most frequent in men. African patients tend to be younger and have a higher proportion of women patients. Different patterns can be observed in the presentation of gastric cancer between different regions of the world. More research is needed in Latin America and Africa since these populations are underrepresented. [Display omitted] •Gastric cancer is a public health problem with high burden of morbidity and mortality.•This malignancy shows a different epidemiology across distinct regions and ethnic groups.•There is similar distribution of driver mutations in different geographic groups.