Moringa oleifera leaves as an inhibitor of human platelet aggregation

Moringa oleifera L. (Moringaceae) leaves were examined for their effect on human platelet aggregation in vitro. The aqueous extract of Moringa oleifera leaves significantly (p ≤ 0.05) inhibited platelet aggregation induced by agonists such as adenosine diphosphate, collagen, and epinephrine. The deg...

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Bibliographic Details
Published inPharmaceutical biology Vol. 47; no. 8; pp. 734 - 739
Main Authors Arabshahi-Delouee, Saeedeh, Aalami, Mehran, Urooj, Asna, Krishnakantha, T.P
Format Journal Article
LanguageEnglish
Published Informa UK Ltd 01.08.2009
Taylor & Francis
Subjects
agonists
chemical concentration
humans
inhibitory activity
leaves
malondialdehyde
medicinal properties
Moringa oleifera
plant extracts
platelet aggregation
protective effect
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Summary:Moringa oleifera L. (Moringaceae) leaves were examined for their effect on human platelet aggregation in vitro. The aqueous extract of Moringa oleifera leaves significantly (p ≤ 0.05) inhibited platelet aggregation induced by agonists such as adenosine diphosphate, collagen, and epinephrine. The degree of inhibitory activity varied depending on the agonist used, concentration of extract and duration of incubating the extract with platelets. Heat treatment reduced the inhibitory activity of extract against platelet aggregation. In addition, the extracts significantly (p ≤ 0.05) decreased the amount of malonaldehyde formed in agonist challenged platelets. This study is the first report on the effect of aqueous extract of Moringa oleifera leaves against human platelet aggregation. Overall, Moringa oleifera leaves have potential to protect platelets against aggregation.
ISSN:1388-0209
1744-5116
DOI:10.1080/13880200902939275