Clinical diagnosis of ocular sarcoidosis

• Published in: Eye (London) Vol. 11; no. 3; pp. 365 - 370
• Main Authors: STAVROU, P, LINTON, S, YOUNG, D. W, MURRAY, P. I
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.01.1997
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers - blood; Eye Diseases - diagnosis; Eye Diseases - enzymology; Female; Follow-Up Studies; Humans; Male; Medical sciences; Middle Aged; Panuveitis - etiology; Peptidyl-Dipeptidase A - blood; Retinal Vein; Retrospective Studies; Sarcoidosis - complications; Sarcoidosis - diagnosis; Sarcoidosis - enzymology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Vasculitis - etiology; Human; Eye; Peptidases; Sarcoidosis; Enzyme; Peptidyl-dipeptidase A; Systemic disease; Hydrolases; Peptidyl-dipeptidases; Serum; Inflammation; Diagnosis
• ISSN: 0950-222X; 1476-5454
• DOI: 10.1038/eye.1997.77

To assess the value of raised serum angiotensin converting enzyme (ACE) levels in making a clinical diagnosis of ocular sarcoidosis in patients with intraocular inflammation, compatible with sarcoidosis, in whom tissue biopsy is either not practical or not possible. The ocular manifestations and clinical course of 22 patients with intraocular inflammation compatible with sarcoidosis and elevated ACE level (including 11 patients with abnormal chest radiograph) were compared with those of a group of 18 patients with intraocular inflammation due to biopsy-proven sarcoidosis. The mean follow-up (+/- SD) was 4.5 +/- 3.4 years in the presumed ocular sarcoidosis group and 7.8 +/- 5.3 years in the biopsy-proven sarcoidosis group. There was no difference in sex, race and age distribution between the two groups. No statistically significant difference could be found between the ocular manifestations seen in each group. The most common finding was retinal vasculitis with panuveitis, seen in 86.4% of the presumed ocular sarcoidosis group and in 83.3% of the biopsy-proven sarcoidosis group. These results suggest that intraocular inflammation compatible with sarcoidosis in conjunction with raised ACE levels would be accordant with a diagnosis of sarcoidosis in patients in whom histological diagnosis is either not practical or not possible.