Mechanism and regulation of the nonsense-mediated decay pathway

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that t...

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Bibliographic Details
Published inNucleic acids research Vol. 44; no. 4; pp. 1483 - 1495
Main Authors Hug, Nele, Longman, Dasa, Cáceres, Javier F
Format Journal Article
LanguageEnglish
Published England Oxford University Press 29.02.2016
Subjects
Codon, Nonsense - genetics
Gene Expression Regulation - genetics
Humans
Metabolic Networks and Pathways - genetics
Nonsense Mediated mRNA Decay - genetics
RNA Helicases - genetics
RNA Stability - genetics
RNA, Messenger - genetics
Survey and Summary
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Abstract The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that tightly regulate the magnitude of this pathway. Here, we will focus on the mechanism of NMD with an emphasis on the role of RNA helicases in the transition from NMD complexes that recognize a PTC to those that promote mRNA decay. We will also review recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NMD pathway. Finally, we will describe recent progress in the study of the physiological role of the NMD response.
AbstractList The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that tightly regulate the magnitude of this pathway. Here, we will focus on the mechanism of NMD with an emphasis on the role of RNA helicases in the transition from NMD complexes that recognize a PTC to those that promote mRNA decay. We will also review recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NMD pathway. Finally, we will describe recent progress in the study of the physiological role of the NMD response.
Author Longman, Dasa
Hug, Nele
Cáceres, Javier F
Author_xml – sequence: 1
  givenname: Nele
  surname: Hug
  fullname: Hug, Nele
  organization: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
– sequence: 2
  givenname: Dasa
  surname: Longman
  fullname: Longman, Dasa
  organization: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
– sequence: 3
  givenname: Javier F
  surname: Cáceres
  fullname: Cáceres, Javier F
  email: Javier.Caceres@igmm.ed.ac.uk
  organization: Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK Javier.Caceres@igmm.ed.ac.uk
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26773057$$D View this record in MEDLINE/PubMed
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Snippet The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a...
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SubjectTerms Codon, Nonsense - genetics
Gene Expression Regulation - genetics
Humans
Metabolic Networks and Pathways - genetics
Nonsense Mediated mRNA Decay - genetics
RNA Helicases - genetics
RNA Stability - genetics
RNA, Messenger - genetics
Survey and Summary
Title Mechanism and regulation of the nonsense-mediated decay pathway
URI https://www.ncbi.nlm.nih.gov/pubmed/26773057
https://search.proquest.com/docview/1769984283
https://pubmed.ncbi.nlm.nih.gov/PMC4770240
Volume 44
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