Mechanism and regulation of the nonsense-mediated decay pathway

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that t...

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Bibliographic Details
Published inNucleic acids research Vol. 44; no. 4; pp. 1483 - 1495
Main Authors Hug, Nele, Longman, Dasa, Cáceres, Javier F
Format Journal Article
LanguageEnglish
Published England Oxford University Press 29.02.2016
Subjects
Codon, Nonsense - genetics
Gene Expression Regulation - genetics
Humans
Metabolic Networks and Pathways - genetics
Nonsense Mediated mRNA Decay - genetics
RNA Helicases - genetics
RNA Stability - genetics
RNA, Messenger - genetics
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Summary:The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that tightly regulate the magnitude of this pathway. Here, we will focus on the mechanism of NMD with an emphasis on the role of RNA helicases in the transition from NMD complexes that recognize a PTC to those that promote mRNA decay. We will also review recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NMD pathway. Finally, we will describe recent progress in the study of the physiological role of the NMD response.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkw010