New resorbable polymeric systems with antithrombogenic activity

The synthesis and application as resorbable coatings of vascular grafts of a new polyacrylic derivative of Triflusal (2-acetyloxy-4-trifluoromethyl)benzoic acid, a commercial drug with antithrombogenic properties, are described. The high-molecular-weight polyacrylic system is rather stable in physio...

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Published inJournal of materials science. Materials in medicine Vol. 10; no. 12; pp. 873 - 878
Main Authors Rodríguez, G, Gallardo, A, San Román, J, Rebuelta, M, Bermejo, P, Buján, J, Bellón, J M, Honduvilla, N G, Escudero, C
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.12.1999
Subjects
Acrylics
Biomedical materials
Carboxylic acids
Materials science
Metabolites
Molecular weight
Pharmacology
Plastic coatings
Polymers
Synthesis (chemical)
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Summary:The synthesis and application as resorbable coatings of vascular grafts of a new polyacrylic derivative of Triflusal (2-acetyloxy-4-trifluoromethyl)benzoic acid, a commercial drug with antithrombogenic properties, are described. The high-molecular-weight polyacrylic system is rather stable in physiological conditions and provides a chemical support for the slow release of the pharmacologically active compound, Triflusal, or its main metabolite (2-hydroxy-4-trifluoromethyl)benzoic acid (HTB). Experiments of deposition and retention of platelets in static basal conditions using plasma-rich medium from blood of sheep, seem to indicate that the polymeric coating of the polyacrylic derivative of Triflusal improves the antiaggregating character for platelets of the surface of small-diameter vascular grafts without the application of other antithrombogenic drugs.
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ISSN:0957-4530
1573-4838
DOI:10.1023/A:1008985302826