Role of miRNAs in mediating organophosphate compounds induced toxicity

• Published in: Toxicology reports Vol. 10; pp. 216 - 222
• Main Authors: Dehghan, Hamideh, Farkhondeh, Tahereh, Darroudi, Majid, Yousefizadeh, Shahnaz, Samarghandian, Saeed
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 2023; Elsevier
• Subjects: MicroRNAs (miRs); Organophosphate compounds; Toxicity; MicroRNAs (miRs); Toxicity; Organophosphate compounds
• ISSN: 2214-7500; 2214-7500
• DOI: 10.1016/j.toxrep.2023.01.007

Organophosphate compounds (OPCs) are a diverse class of chemicals utilized in both industrial and agricultural settings. The exact molecular pathways that OPCs-induced toxicity is caused by are still being investigated, despite the fact that studies on this topic have been ongoing for a long time. As a result, it's important to identify innovative strategies to uncover these processes and further the understanding of the pathways involved in OPCs-induced toxicity. In this context, determining the role of microRNAs (miRs) in the toxicity caused by OPCs should be taken into consideration. Recent research on the regulation function of miRs presents key discoveries to identify any gaps in the toxicity mechanisms of OPCs. As diagnostic indicators for toxicity in people exposed to OPCs, various expression miRs can also be used. The results of experimental and human studies into the expression profiles of miRs in OPCs-induced toxicity have been compiled in this article. [Display omitted] •miRNA families involved in OPCs-induced organ toxicity.•miRNAs may serve as diagnostic biomarkers for exposure to OPCs.•miRNA families involved in OPCs-induced oxidative stress.