Conserved OprF as a Selective Immunogen against Pseudomonas aeruginosa

Due to the importance of in severe inpatient infections and high mortality, the need for an efficient vaccine against these bacteria is increasing. In this regard, the general outer membrane porin of the most problematic microorganism , outer membrane protein F (OprF), is a good vaccine candidate. T...

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Published inIranian journal of pathology Vol. 12; no. 2; pp. 165 - 170
Main Authors Kazemi Moghaddam, Ehsan, Owlia, Parviz, Jahangiri, Abolfazl, Rasooli, Iraj, Rahbar, Mohammad Reza, Aghajani, Marjan
Format Journal Article
LanguageEnglish
Published Iran Iranian Society of Pathology 2017
Subjects
opf protein
Original
pseudomonas aeruginosa
vaccine
Pseudomonas aeruginosa
OprF Protein
Vaccine
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Summary:Due to the importance of in severe inpatient infections and high mortality, the need for an efficient vaccine against these bacteria is increasing. In this regard, the general outer membrane porin of the most problematic microorganism , outer membrane protein F (OprF), is a good vaccine candidate. The databank of NCBI was used to retrieve protein sequences recorded for OprF in The current study aimed at investigating the conservation of the OprF in 150 reference sequences, clinical, and environmental strains of from different countries via bioinformatic tools.T-COFFEE and PRALINE software were used for alignment. Of these, 134 strains were isolated from clinical specimens and other strains from environmental samples. Evaluation of alignment by the mentioned software clearly showed that this protein was conserved. Antigenicity and grand average of hydropathicity were favorable. Conservation of OprF in all pathogenic and environmental strains of indicated that it can be considered as a good immunogen; however, the protectivity of OprF should be validated experimentally.
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ISSN:1735-5303
2345-3656
DOI:10.30699/ijp.2017.24875