Brain tissue from persons dying of Creutzfeldt-Jakob disease causes scrapie-like encephalopathy in goats

Two goats became affected with an encephalopathy indistinguishable from scrapie 43 months after they were inoculated intracerebrally with 10% suspensions of brain from two persons dying of Creutzfeldt-Jakob disease. Although this observation does not establish the common identity of Creutzfeldt-Jako...

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Bibliographic Details
Published inAnnals of neurology Vol. 8; no. 6; p. 628
Main Authors Hadlow, W J, Prusiner, S B, Kennedy, R C, Race, R E
Format Journal Article
LanguageEnglish
Published United States 01.12.1980
Subjects
Aged
Animals
Brain - microbiology
Brain - pathology
Brain Diseases - pathology
Brain Diseases - transmission
Brain Diseases - veterinary
Creutzfeldt-Jakob Syndrome - etiology
Creutzfeldt-Jakob Syndrome - pathology
Creutzfeldt-Jakob Syndrome - transmission
Female
Goats
Humans
Male
Middle Aged
Scrapie - etiology
Sheep
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Summary:Two goats became affected with an encephalopathy indistinguishable from scrapie 43 months after they were inoculated intracerebrally with 10% suspensions of brain from two persons dying of Creutzfeldt-Jakob disease. Although this observation does not establish the common identity of Creutzfeldt-Jakob disease virus and scrapie virus, it is thought to provide strong evidence of a close etiological relationship between the two diseases.
ISSN:0364-5134
DOI:10.1002/ana.410080615