The oncomodulatory role of human cytomegalovirus in colorectal cancer: implications for clinical trials

Increasing evidence suggests that human cytomegalovirus (HCMV), a beta-herpes virus that chronically infects human beings, is associated with colorectal cancer (CRC). The viral nucleic acids specifically localized to the neoplastic mucosal epithelium of CRC, while tumoral presence of HCMV independen...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in oncology Vol. 4; p. 314
Main Authors Chen, Hsin-Pai, Chan, Yu-Jiun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2014
Subjects
anti-cancer immunity
Anti-cancer therapy
colorectal cancer
Human Cytomegalovirus
Oncology
oncomodulation
anti-cancer immunity
anti-cancer therapy
colorectal cancer
oncomodulation
human cytomegalovirus
Online AccessGet full text

Cover

More Information
Summary:Increasing evidence suggests that human cytomegalovirus (HCMV), a beta-herpes virus that chronically infects human beings, is associated with colorectal cancer (CRC). The viral nucleic acids specifically localized to the neoplastic mucosal epithelium of CRC, while tumoral presence of HCMV independently predicted a poor outcome in elderly patients. In the past decade, the concept of "oncomodulation" of HCMV in human cancers has been formulated. In CRC, changes in the tumor microenvironment are closely related to cancer behavior and prognosis, while the underlying mechanism driving these changes remains unclear. As HCMV affects multiple cellular functions, including signal pathways that regulate angiogenesis, apoptosis, cell invasiveness, and anti-cancer immunity, the virus potentially exerts oncomodulatory effects in the tumor microenvironment of CRC. Here, we summarize the current knowledge about the association between HCMV and CRC and suggest future perspectives on both research and anti-cancer therapy of CRC.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Sathish Kumar Mungamuri, Mount Sinai School of Medicine, USA; Shashidhar Jatiani, Mount Sinai Medical Center, USA
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology.
Edited by: Charles Stringfellow Cobbs, Swedish Neuroscience Institute, USA
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2014.00314