Twitch and tetanus in mdx mouse muscle

We compared mdx and C57BL10 anterior tibial muscle force in situ (single pulse, multiple pulse, staircase, posttetanic potentiation, and fatiguing stimulation patterns) to define muscle strength, physiology, and fatigue resistance. The relatively hypertrophied mdx muscle showed: reduced strength (N/...

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Bibliographic Details
Published inMuscle & nerve Vol. 15; no. 7; p. 837
Main Authors Quinlan, J G, Johnson, S R, McKee, M K, Lyden, S P
Format Journal Article
LanguageEnglish
Published United States 01.07.1992
Subjects
Animals
Mice
Mice, Inbred C57BL
Muscle Contraction - physiology
Muscles - physiopathology
Muscular Dystrophy, Animal - physiopathology
Tibia
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Summary:We compared mdx and C57BL10 anterior tibial muscle force in situ (single pulse, multiple pulse, staircase, posttetanic potentiation, and fatiguing stimulation patterns) to define muscle strength, physiology, and fatigue resistance. The relatively hypertrophied mdx muscle showed: reduced strength (N/cm2), an increased twitch-tetanus ratio, and resistance to post-fatigue twitch slowing. These differences implicate altered mdx calcium regulation, and emphasize the importance of measuring both muscle function and morphology in mdx treatment trials.
ISSN:0148-639X
DOI:10.1002/mus.880150713