Epidemiologic Problems Associated with Exposure to Several Agents
Simultaneous exposure to many potentially hazardous agents in the environment is the rule, yet there have been few studies that have addressed the issue of interactions of these agents in modifying disease outcomes, even though such interactions may potentially be important in terms of policy-making...
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| Published in | Environmental health perspectives Vol. 42; pp. 51 - 56 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
01.12.1981
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Simultaneous exposure to many potentially hazardous agents in the environment is the rule, yet there have been few studies that have addressed the issue of interactions of these agents in modifying disease outcomes, even though such interactions may potentially be important in terms of policy-making. Epidemiological methods may be an important way to identify interaction effects, especially for chronic disease outcomes. Some examples of epidemiologic investigations of this problem are given, and a matrix method used to evaluate the contribution of nineteen chemicals to the risk of liver angiosarcoma in vinyl chloride workers is discussed. |
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| AbstractList | Simultaneous exposure to many potentially hazardous agents in the environment is the rule, yet there have been few studies that have addressed the issue of interactions of these agents in modifying disease outcomes, even though such interactions may potentially be important in terms of policy-making. Epidemiological methods may be an important way to identify interaction effects, especially for chronic disease outcomes. Some examples of epidemiologic investigations of this problem are given, and a matrix method used to evaluate the contribution of nineteen chemicals to the risk of liver angiosarcoma in vinyl chloride workers is discussed. Simultaneous exposure to many potential hazardous agents in the environment in the rule, yet there have been few studies that have addressed the issue of interactions of these agents in modifying disease outcomes, even though such interactions may potentially be important in terms of policy-making. Epidemiological methods may be an important way to identify interaction effects, especially for chronic disease outcomes. Some examples of epidemiologic investigations of this problem are given, and a matrix method used to evaluate the contribution of nineteen chemicals to the risk of liver angiosarcoma in vinyl chloride workers is discussed. |
| Author | Waxweiler, Richard J. |
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| References | 1170818 - Arch Environ Health. 1975 Jul;30(7):333-9 629894 - Br J Ind Med. 1978 Feb;35(1):8-15 4361970 - Health Phys. 1973 Oct;25(4):351-71 4472855 - Arch Environ Health. 1974 Nov;29(5):250-5 14306333 - N Engl J Med. 1965 Jul 22;273:181-8 4456884 - Work Environ Health. 1974;11(1):21-8 7365554 - J Occup Med. 1980 Mar;22(3):171-6 |
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| SubjectTerms | Air Pollutants, Occupational - poisoning Arsenic Carcinogens Chemical hazards Chlorides Drug Interactions Epidemiologic Methods Epidemiology Ethers First Annual Symposium on Environmental Epidemiology. Pittsburgh, PA. April 28-30, 1980 Hemangiosarcoma - chemically induced Humans Liver Neoplasms - chemically induced Lung neoplasms Mining Occupational Diseases - chemically induced Radon Retrospective Studies Uranium Vinyl Chloride - poisoning |
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| Title | Epidemiologic Problems Associated with Exposure to Several Agents |
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