Epidemiologic Problems Associated with Exposure to Several Agents

Simultaneous exposure to many potentially hazardous agents in the environment is the rule, yet there have been few studies that have addressed the issue of interactions of these agents in modifying disease outcomes, even though such interactions may potentially be important in terms of policy-making...

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Bibliographic Details
Published inEnvironmental health perspectives Vol. 42; pp. 51 - 56
Main Author Waxweiler, Richard J.
Format Journal Article
LanguageEnglish
Published United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01.12.1981
Subjects
Air Pollutants, Occupational - poisoning
Arsenic
Carcinogens
Chemical hazards
Chlorides
Drug Interactions
Epidemiologic Methods
Epidemiology
Ethers
First Annual Symposium on Environmental Epidemiology. Pittsburgh, PA. April 28-30, 1980
Hemangiosarcoma - chemically induced
Humans
Liver Neoplasms - chemically induced
Lung neoplasms
Mining
Occupational Diseases - chemically induced
Radon
Retrospective Studies
Uranium
Vinyl Chloride - poisoning
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Summary:Simultaneous exposure to many potentially hazardous agents in the environment is the rule, yet there have been few studies that have addressed the issue of interactions of these agents in modifying disease outcomes, even though such interactions may potentially be important in terms of policy-making. Epidemiological methods may be an important way to identify interaction effects, especially for chronic disease outcomes. Some examples of epidemiologic investigations of this problem are given, and a matrix method used to evaluate the contribution of nineteen chemicals to the risk of liver angiosarcoma in vinyl chloride workers is discussed.
Bibliography:ObjectType-Article-2
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ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.814251