Glycotoxines, carbonyl stress and relevance to diabetes and its complications

A large body of evidence has implicated reactive carbonyl compounds as glycotoxic mediators of carbonyl stress. This review is focused on the pathophysiological effects of alpha oxoaldehydes in diabetes and related complications, summarizing the state-of-the-art on the endogenously produced carbonyl...

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Bibliographic Details
Published inPhysiological research Vol. 59; no. 2; pp. 147 - 156
Main Author Turk, Z
Format Journal Article
LanguageEnglish
Published Czech Republic Institute of Physiology 01.01.2010
Subjects
Amino acids
Apoptosis
Biosynthesis
Chemical reactions
Diabetes
Diabetes Complications - metabolism
Glycation End Products, Advanced - metabolism
Humans
Hyperglycemia
Metabolic disorders
Metabolites
Molecular weight
Oxidative Stress - physiology
Pathology
Plasma
Proteins
Pyruvaldehyde - metabolism
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Summary:A large body of evidence has implicated reactive carbonyl compounds as glycotoxic mediators of carbonyl stress. This review is focused on the pathophysiological effects of alpha oxoaldehydes in diabetes and related complications, summarizing the state-of-the-art on the endogenously produced carbonyls methylglyoxal, glyoxal and 3-deoxyglucosone, formed as glycolytic intermediates during metabolic conversion of glucose, via Maillard reaction by degradation of glycated proteins, and during lipid peroxidation process. Their role in the advanced glycation process and detrimental effects on vascular tissue are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.931585