New efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones via an oxazolyliminophosphorane

A new efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones by consecutive aza-Wittig reaction was developed. A new efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones by consecutive aza-Wittig reaction was developed. The sequential three-component r...

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Bibliographic Details
Published inChinese chemical letters Vol. 26; no. 9; pp. 1158 - 1160
Main Authors Zeng, Guo-Ping, Cai, Chang-Quan, Tan, Fen, Ding, Ming-Wu
Format Journal Article
LanguageEnglish
Published NEW YORK Elsevier B.V 01.09.2015
Elsevier
Subjects
Aza-Wittig reaction
Carbodiimide
Chemistry
Chemistry, Multidisciplinary
Iminophosphorane
Oxazolo[5,4-d]pyrimidi-7(6H)-one
Physical Sciences
Science & Technology
Iminophosphorane
Aza-Wittig reaction
Carbodiimide
Oxazolo[5,4-d]pyrimidi-7(6H)-one
OXAZOLES
DERIVATIVES
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Summary:A new efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones by consecutive aza-Wittig reaction was developed. A new efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones by consecutive aza-Wittig reaction was developed. The sequential three-component reaction of oxazolyliminophosphorane 4, isocyanates and amines produced 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones 7 in good overall yields in the presence of catalytic amount of EtONa.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2015.06.011