Coordination chemistry of metals in medicine: target sites for bismuth

Bismuth compounds are used for the treatment of gastrointestinal disorders and may also be useful for the treatment of other diseases. Bi(III) exhibits a highly variable coordination number (3–10) and often an irregular coordination geometry. The coordination chemistry of Bi(III) with carboxylates a...

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Published inCoordination chemistry reviews Vol. 185; pp. 689 - 709
Main Authors Sadler, Peter J, Li, Hongyan, Sun, Hongzhe
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.1999
Subjects
Anti-ulcer
Bioinorganic chemistry
Bismuth
Metallodrugs
Bismuth
Bioinorganic chemistry
Metallodrugs
Anti-ulcer
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Summary:Bismuth compounds are used for the treatment of gastrointestinal disorders and may also be useful for the treatment of other diseases. Bi(III) exhibits a highly variable coordination number (3–10) and often an irregular coordination geometry. The coordination chemistry of Bi(III) with carboxylates and aminocarboxylates is dominated by intermolecular interactions which leads to polymeric structures. Bi(III) binds strongly to the thiolate sulfur of the tripeptide glutathione, however these adducts are also kinetically labile which allows rapid translocation of Bi(III) inside cells. The major biological target for Bi(III) appears to be proteins and enzymes. Bi(III) binds to both Zn(II) sites (e.g. metallothionein) and Fe(III) sites (e.g. transferrin and lactoferrin) in proteins and enzymes and inhibits the bacterial Ni enzyme urease.
ISSN:0010-8545
1873-3840
DOI:10.1016/S0010-8545(99)00018-1