Megastigmane glucosides isolated from Dichrocephala benthamii

• Published in: Chinese journal of natural medicines Vol. 15; no. 4; pp. 288 - 291
• Main Authors: SONG, Bo, SI, Jin-Guang, YU, Meng, TIAN, Xiao-Hui, DING, Gang, ZOU, Zhong-Mei
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.04.2017
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Asteraceae; Asteraceae - chemistry; chemical composition; China; Cyclohexanones - chemistry; Cyclohexanones - isolation & purification; Cyclohexanones - pharmacology; Cytotoxicity; Dichrocephala benthamii; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - isolation & purification; glucosides; Glucosides - chemistry; Glucosides - isolation & purification; Glucosides - pharmacology; Hep G2 Cells; hepatoma; Humans; Megastigmane glucoside; Molecular Structure; Norisoprenoids - chemistry; Norisoprenoids - isolation & purification; Norisoprenoids - pharmacology; nuclear magnetic resonance spectroscopy; Oriental traditional medicine; Plants, Medicinal; spectral analysis; Megastigmane glucoside; Cytotoxicity; Asteraceae; Dichrocephala benthamii
• ISSN: 1875-5364; 1875-5364
• DOI: 10.1016/S1875-5364(17)30046-8

The present study was designed to investigate the chemical constituents of the whole herb of Dichrocephala benthamii. A new megastigmane glucoside (compound 1), together with its four known analogues (compounds 2−5), was obtained. Their structures were elucidated on the basis of spectroscopic analyses (UV, IR, MS, and 1D and 2D NMR). The absolute configuration of compound 1 was assigned on the basis of CD method and chemical evidence. In addition, their cytotoxicity against human hepatoma cells (HepG-2) was evaluated by the MTT method. Compound 5 showed weak activity against HepG-2, while the other compounds did not show remarkable inhibitory effects.