Sequelae and complications related to dental extractions in patients with hematologic malignancies and the impact on medical outcome

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 92; no. 1; pp. 49 - 55
• Main Authors: Raut, Alexandra, Huryn, Joseph M., Hwang, Freeman R., Zlotolow, Ian M.
• Format: Journal Article
• Language: English
• Published: St. Louis, MO Mosby, Inc 01.07.2001; Elsevier
• Subjects: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Bone Marrow Transplantation; Child; Chronic Disease; Dentistry; Female; Follow-Up Studies; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics; Hematologic and hematopoietic diseases; Hematologic Neoplasms - complications; Hematologic Neoplasms - physiopathology; Hematologic Neoplasms - therapy; Hospitalization; Humans; Length of Stay; Leukemia - complications; Leukemia - physiopathology; Leukemia - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Maxillofacial surgery. Dental surgery. Orthodontics; Medical sciences; Middle Aged; Multiple Myeloma - complications; Multiple Myeloma - physiopathology; Multiple Myeloma - therapy; Myelodysplastic Syndromes - complications; Myelodysplastic Syndromes - physiopathology; Myelodysplastic Syndromes - therapy; Postoperative Complications; Retrospective Studies; Statistics as Topic; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Rate; Time Factors; Tooth Extraction - adverse effects; Treatment Outcome; Human; Concomitant disease; Surgery; Complication; Sequela; Extraction; Malignant hemopathy; Tooth; Retrospective
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1067/moe.2001.113588

Objective: The purpose of this retrospective study was to evaluate sequelae and complications after dental extractions and to analyze their impact on medical treatment in patients with myelodysplastic syndrome, acute and chronic leukemia, and multiple myeloma during a 3-year period. Study Design: The study population included 388 patients with hematologic malignancies. All medical and dental charts were reviewed in a retrospective fashion to identify patients who received dental extractions. Preexisting dental disease and intervention (extraction) were evaluated, and parameters such as days of hospitalization and survival rate were compared with those of the remainder population who did not receive dental extractions. Results: Of the 388 patients, 69 underwent dental extractions and 9 had sequelae and complications after the intervention. The resulting complication rate of 13% was reported. Although some patients did experience delay of chemotherapy or bone marrow transplant (BMT), or both, no significant difference was found in the number of days in the hospital for BMT and the survival rate for the patients with sequelae and complications (n = 9) and for the remainder population (n = 319) ( >.05). Conclusion: Dental extraction intervention provided in the prechemotherapy and pre-BMT time frame did not have a negative bearing on medical outcome. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92:4955)