The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy

• Published in: Journal of perinatal medicine Vol. 44; no. 3; pp. 277 - 281
• Main Authors: So, Jane, Young, Elizabeth, Crnosija, Natalie, Chappelle, Joseph
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.04.2016; Walter de Gruyter GmbH
• Subjects: Adult; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Creatinine - blood; Female; Gestational hypertension; HELLP syndrome; Humans; Hypertension; Hypertension, Pregnancy-Induced - blood; Hypertension, Pregnancy-Induced - diagnosis; Hypertension, Pregnancy-Induced - mortality; L-Lactate Dehydrogenase - blood; Laboratories; Maternal Mortality; Platelet Count; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Pre-Eclampsia - mortality; Predictive Value of Tests; Preeclampsia; Pregnancy; Retrospective Studies; Young Adult
• ISSN: 0300-5577; 1619-3997
• DOI: 10.1515/jpm-2015-0089

Preeclampsia is the 2 leading cause of maternal mortality in the United States. Women with new-onset or worsening hypertension are commonly evaluated for laboratory abnormalities. We aim to investigate whether demographic and/or clinical findings correlate with abnormal laboratory values. A retrospective chart review of women who presented for evaluation of hypertension in pregnancy during 2010. Demographic information, medical history, symptoms, vital signs, and laboratory results were collected. Bivariate analysis was used to investigate associations between predictors and the outcome. Of the 481 women in the sample, 22 were identified as having abnormal laboratory test results (4.6%). Women who reported right upper quadrant pain or tenderness had significantly increased likelihood of having laboratory abnormalities compared to those without the complaint. Only a small percentage of women evaluated were determined to have abnormal laboratory findings, predominantly among women with severe preeclampsia. Right upper quadrant pain or tenderness was positively correlated with laboratory abnormalities. The restriction of laboratory analysis in women with clinical evidence of severe disease may be warranted – a broader study should, however, first be used to confirm our findings.