Bacterial derived proteoliposome for allergy vaccines

One current approach in developing anti allergic vaccines is the use of potent adjuvants, capable of inducing Th1 or T regulatory cells. Proteoliposomes (PL) could be a suitable adjuvant. Purified Dermatophagoides siboney (Ds) allergens were mixed with PL and adsorbed into Al(OH) 3 and evaluated in...

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Published inVaccine Vol. 24; pp. S34 - S35
Main Authors Lastre, Miriam, Pérez, Oliver, Labrada, Alexis, Bidot, Igor, Pérez, Jorge, Bracho, Gustavo, Campo, Judith del, Pérez, Dainerys, Facenda, Elisa, Zayas, Caridad, Rodríguez, Claudio, Sierra, Gustavo
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.04.2006
Subjects
Adjuvant
Allergen
Bacteria
Dermatophagoides
Dermatophagoides siboney
Proteoliposome
Proteoliposome
Adjuvant
Allergen
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Summary:One current approach in developing anti allergic vaccines is the use of potent adjuvants, capable of inducing Th1 or T regulatory cells. Proteoliposomes (PL) could be a suitable adjuvant. Purified Dermatophagoides siboney (Ds) allergens were mixed with PL and adsorbed into Al(OH) 3 and evaluated in mice. The Th1/Th2 responses were measured at classes, subclasses, cytokines, and DTH levels. Anti Ds response was deviated to a Thl pattern, with the production of IgG2a and γlFN. A positive DTH response and a dramatic decrease of specific IgE and IL5 were not detected. The low dose was more effective than high dose. These results clearly support the potential use of PL as possible adjuvants for anti-allergic vaccines.
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content type line 23
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.01.110