Practical preparation and substitution of configurationally stable aziridinyl ester anions

Configurationally and chemically stable aziridine carboxylate anions have been generated. These intermediates are stable at −78°C for several hours and react with electrophiles with good to excellent retention of configuration.

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Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 5; pp. 651 - 654
Main Authors Alezra, Valérie, Bonin, Martine, Micouin, Laurent, Husson, Henri-Philippe
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.01.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
C-ALKYLATION
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Summary:Configurationally and chemically stable aziridine carboxylate anions have been generated. These intermediates are stable at −78°C for several hours and react with electrophiles with good to excellent retention of configuration.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(99)02156-5