Rapid, Routine Method for the Analysis of Some Drugs with Bromate and Celestine Blue

A simple and sensitive method is proposed for the spectrophotometric determination of drugs, viz. isoniazid, trimeprazine tartarate, pyridoxine HCl and captopril based on their reactivity with potassium bromate. The method involves the addition of excess KBrO 3 of known concentration in the presence...

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Bibliographic Details
Published inAnalytical letters Vol. 31; no. 2; pp. 263 - 273
Main Authors Sastry, Chilukuri S. P., Rao, Sankuratripati Gopala, Naidu, Petla Y., Srinivas, K. Rama
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Taylor & Francis Group 01.01.1998
Taylor & Francis
Subjects
Analysis
Biological and medical sciences
captopril
celestine blue
General pharmacology
isoniazid
Medical sciences
Pharmacology. Drug treatments
potassium bromate
pyridoxine HCl
spectrophotometry
trimeprazine tartarate
Trace analysis
Alkali metal Compounds
Potassium Bromates
Chemical analysis
Captopril
Pyridoxine
Aqueous solution
Isoniazid
Oxazine dye
Quantitative analysis
Ultraviolet visible spectrometry
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Summary:A simple and sensitive method is proposed for the spectrophotometric determination of drugs, viz. isoniazid, trimeprazine tartarate, pyridoxine HCl and captopril based on their reactivity with potassium bromate. The method involves the addition of excess KBrO 3 of known concentration in the presence of 0.7M HCl and the unreacted KBrO 3 is determined by the measurement of the decrease in the absorbance of the dye, celestine blue (Λ max 540 nm). This method was applied to the determination of drug contents in pharmaceutical formulations and enabled the determination of the drugs in microgram quantities (0.4-4.0 μg.ml −1 ).
ISSN:0003-2719
1532-236X
DOI:10.1080/00032719808002044