1ST STEREOSELECTIVE SYNTHESIS OF D-AMINO-ACID N-ALKYL AMIDE CATALYZED BY D-AMINOPEPTIDASE

The first stereoselective synthesis of D-amino acid N-alkyl amides was achieved by the use of D-aminopeptidase from Ochrobactrum anthropi. The enzyme immobilized by urethane prepolymer PU-6 catalyzed aminolysis reaction of racemic amino acid esters in organic solvents.

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Bibliographic Details
Published inTetrahedron Vol. 45; no. 18; pp. 5743 - 5754
Main Authors KATO, Y, ASANO, Y, NAKAZAWA, A, KONDO, K
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.01.1989
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:The first stereoselective synthesis of D-amino acid N-alkyl amides was achieved by the use of D-aminopeptidase from Ochrobactrum anthropi. The enzyme immobilized by urethane prepolymer PU-6 catalyzed aminolysis reaction of racemic amino acid esters in organic solvents.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(01)89103-1