Efficient reaction pathway for the synthesis of saturated and mono-unsaturated 2-alkylcyclobutanones

A synthetic pathway leading to saturated and mono-unsaturated 2-alkylcyclobutanones has been developed and proved to be very efficient and fast to realize. It was used to produce gram amounts of different 2-alkylcyclobutanones with saturated and mono-unsaturated alkyl side chain (2-decyl-, 2-dodecyl...

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Bibliographic Details
Published inRadiation physics and chemistry (Oxford, England : 1993) Vol. 65; no. 3; pp. 233 - 239
Main Authors Miesch, M, Miesch, L, Horvatovich, P, Burnouf, D, Delincée, H, Hartwig, A, Raul, F, Werner, D, Marchioni, E
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.10.2002
Subjects
2-alkylcyclobutanones
Food
Irradiation
Synthesis
Irradiation
Synthesis
2-alkylcyclobutanones
Food
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Summary:A synthetic pathway leading to saturated and mono-unsaturated 2-alkylcyclobutanones has been developed and proved to be very efficient and fast to realize. It was used to produce gram amounts of different 2-alkylcyclobutanones with saturated and mono-unsaturated alkyl side chain (2-decyl-, 2-dodecyl-, 2-dodecenyl-, 2-tetradecyl- and 2-tetradecenyl-cyclobutanone), necessary for in vitro and in vivo biological studies. The excellent chromatographic characteristics (purity better than 97%) of the synthesized compounds made it also possible to use them as chromatographic reference samples for the analysis of irradiated foodstuffs.
ISSN:0969-806X
1879-0895
DOI:10.1016/S0969-806X(02)00265-7