Cyclogossine A: A novel cyclic heptapeptide isolated from the latex of Jatropha gossypifolia

From the latex of Jatropha gossypifolia L. (Euphorbiaceae) a novel cyclic heptapeptide was isolated, which we named cyclogossine A. A combination of amino acid analysis, FAB mass spectrometry, and two dimensional 1H-NMR spectroscopy (TOCSY and ROESY) was used to determine the primary structure. The...

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Bibliographic Details
Published inPlanta medica Vol. 62; no. 1; p. 46
Main Authors Horsten, S.F.A.J, Berg, A.J.J. van den, Bosch, J.J.K. van den, Leeflang, B.R, Labadie, R.P. (Utrecht Univ. (Netherlands). Faculty of Pharmacy. Dept. of Pharmacognosy)
Format Journal Article
LanguageEnglish
Published Germany 01.02.1996
Subjects
Amino Acid Sequence
Chromatography, Gas
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
ESTRUCTURA QUIMICA
JATROPHA
LATEX
Latex - chemistry
Magnetic Resonance Spectroscopy
Molecular Sequence Data
PEPTIDE
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
PEPTIDOS
PLANTAS MEDICINALES
PLANTE MEDICINALE
Spectrometry, Mass, Fast Atom Bombardment
STRUCTURE CHIMIQUE
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Summary:From the latex of Jatropha gossypifolia L. (Euphorbiaceae) a novel cyclic heptapeptide was isolated, which we named cyclogossine A. A combination of amino acid analysis, FAB mass spectrometry, and two dimensional 1H-NMR spectroscopy (TOCSY and ROESY) was used to determine the primary structure. The compound was found to contain one glycine, one alanine, one valine, two leucine, one threonine, and one tryptophan residue; its amino acid sequence is: Leu 1-Ala 2 - Thr 3 - Trp 4 - Leu 5 - Gly 6 - Val 7. The absolute configurations of the amino acids were determined by chiral gas chromatography; all have the L-configuration.
Bibliography:F60
97B7607
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-957795