A solid-phase combinatorial method for the synthesis of novel 5- and 6-membered ring lactams

• Published in: Tetrahedron letters Vol. 38; no. 3; pp. 359 - 362
• Main Authors: Short, Kevin M., Mjalli, Adnan M.M.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.01.1997; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; TECHNOLOGIES; DRUG DISCOVERY

The synthesis of small-ring lactams via the condensation of ω-ketoacids, isocyanides and amines is reported. This process is shown to proceed well in a combinatorial fashion, by immobilization of the isocyanide component on Wang resin. The product is then released from the support on treatment with...