A solid-phase combinatorial method for the synthesis of novel 5- and 6-membered ring lactams

The synthesis of small-ring lactams via the condensation of ω-ketoacids, isocyanides and amines is reported. This process is shown to proceed well in a combinatorial fashion, by immobilization of the isocyanide component on Wang resin. The product is then released from the support on treatment with...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 3; pp. 359 - 362
Main Authors Short, Kevin M., Mjalli, Adnan M.M.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.01.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
TECHNOLOGIES
DRUG DISCOVERY
Online AccessGet full text

Cover

More Information
Summary:The synthesis of small-ring lactams via the condensation of ω-ketoacids, isocyanides and amines is reported. This process is shown to proceed well in a combinatorial fashion, by immobilization of the isocyanide component on Wang resin. The product is then released from the support on treatment with 10% TFA/CH 2Cl 2 The synthesis of small-ring lactams via the condensation of ω-ketoacids, isocyanides and amines is reported, both in solution and solid-phase.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(96)02303-9