The design and synthesis of simple molecular tethers for binding biomembranes to a gold surface

Molecular tethers have been synthesised for fixing biomembranes to a gold surface. These are comprised of a thiol at one end to bind to the gold, a polyethylenoxy chain of defined length (two, six or twelve ethylenoxy units) in the middle and a cholesteryl residue at the other end to insert into the...

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Bibliographic Details
Published inTetrahedron Vol. 53; no. 31; pp. 10939 - 10952
Main Authors Boden, Neville, Bushby, Richard J., Clarkson, Steven, Evans, Stephen D., Knowles, Peter F., Marsh, Andrew
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 04.08.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MEMBRANES
ATTACHMENT
LIPID BILAYERS
LAYERS
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Summary:Molecular tethers have been synthesised for fixing biomembranes to a gold surface. These are comprised of a thiol at one end to bind to the gold, a polyethylenoxy chain of defined length (two, six or twelve ethylenoxy units) in the middle and a cholesteryl residue at the other end to insert into the biomembrane. Cholesterol conjugates such as that shown have been prepared for the formation of mixed self-assembled monolayers which can fix a biomembrane to a gold surface.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(97)00698-4