A novel synthesis of disubstituted ureas using titanium(IV) isopropoxide and sodium borohydride

This paper describes a high yield preparation of unsymmetrically disubstituted ureas by a titanium(IV) isopropoxide/sodium borohydride mediated reductive amidation of aromatic aldehydes with monosubstituted ureas. This paper describes a high yield preparation of unsymmetrically disubstituted ureas b...

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Bibliographic Details
Published inTetrahedron letters Vol. 38; no. 9; pp. 1531 - 1532
Main Authors Armstrong, Joseph D., Wolfe, Chad N., Keller, Jennifer L., Lynch, Joseph, Bhupathy, M., Volante, R.P., De Vita, Robert J.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 03.03.1997
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:This paper describes a high yield preparation of unsymmetrically disubstituted ureas by a titanium(IV) isopropoxide/sodium borohydride mediated reductive amidation of aromatic aldehydes with monosubstituted ureas. This paper describes a high yield preparation of unsymmetrically disubstituted ureas by a titanium(IV) isopropoxide/sodium borohydride mediated reductive amidation of aromatic aldehydes with monosubstituted ureas.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)00149-4