Osseous involvement in pediatric Hodgkin’s lymphoma

• Published in: Indian journal of pediatrics Vol. 77; no. 5; pp. 565 - 566
• Main Authors: Singh, Preetpaul, Bakhshi, Sameer
• Format: Journal Article
• Language: English
• Published: India Springer-Verlag 01.05.2010; Springer
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biopsy; Bone Neoplasms - diagnosis; Bone Neoplasms - secondary; Bone Neoplasms - therapy; Child; Clinical Brief; Combined Modality Therapy; Contrast Media; Diagnosis, Differential; Female; General aspects; Gynecology; Hematologic and hematopoietic diseases; Hodgkin Disease - diagnosis; Hodgkin Disease - pathology; Hodgkin Disease - therapy; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Medicine; Medicine & Public Health; Pediatrics; Tomography, X-Ray Computed; Radiography; Clinical characteristics; Bone; Pediatric; Hodgkin’s lymphoma; Human; Pediatrics; Radiodiagnosis; Exploration; Hodgkin disease; Malignant hemopathy; Lymphoma; Symptomatology; Lymphoproliferative syndrome; Tropical medicine; Child; Cancer; Hodgkin's lymphoma
• ISSN: 0019-5456; 0973-7693
• DOI: 10.1007/s12098-010-0019-z

Presented here is a report of 3 children, out of 66 total pediatric Hodgkin’s lymphoma (HL) patients (4.5%) with bone involvement over a 3 and a half year period. Two patients presented with osseous lesions at the time of relapse and one had concurrent evidence of non-osseous disease. The clinical presentation, radiographic findings, histology, treatment and outcome of these patients are discussed. Boys and girls are nearly equally affected, local bone pain is the commonest symptom and B-symptoms are common. Vertebrae and pelvis are most frequently involved, commonly with an osteolytic picture. Nodular sclerosis is the predominant histological subtype. Most children received combined modality treatment and the overall response and survival are good.