Efficient synthesis of hydrophilic phosphodiester derivatives of lipophilic alcohols via the glycosyl hydrogenphosphonate method

The preparation of five peracetylated a-glycosyl-H-phosphonates and their use in the straightforward preparation of phosphodiesters derivatives of 25-hydroxycholesterol is described. Examples of the extension of this process to other lipophilic alcohols are presented. The use of peracetylated -α-gly...

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Bibliographic Details
Published inTetrahedron letters Vol. 39; no. 3; pp. 273 - 274
Main Authors Knerr, Laurent, Pannecoucke, Xavier, Luu, Bang
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.01.1998
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:The preparation of five peracetylated a-glycosyl-H-phosphonates and their use in the straightforward preparation of phosphodiesters derivatives of 25-hydroxycholesterol is described. Examples of the extension of this process to other lipophilic alcohols are presented. The use of peracetylated -α-glycosyl H-phosphonates as building blocks for the straightforward preparation of phosphodiesters derivatives of lipophilic alcohols is described.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(97)10510-X