Mild and regioselective oxidative bromination of anilines using potassium bromide and sodium perborate

The selective monobromination of various deactivated anilines using potassium bromide and sodium perborate as oxidant has been achieved. The use of ammonium molybdate as catalyst accelerates the rate of reaction but is not essential to obtain good yields and high selectivities.

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Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 13; pp. 2083 - 2085
Main Authors Roche, Didier, Prasad, Kapa, Repic, Oljan, Blacklock, Thomas J
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 27.03.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
AROMATIC-AMINES
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Summary:The selective monobromination of various deactivated anilines using potassium bromide and sodium perborate as oxidant has been achieved. The use of ammonium molybdate as catalyst accelerates the rate of reaction but is not essential to obtain good yields and high selectivities.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00119-2