Lepirudin anticoagulation for heparin-induced thrombocytopenia

Lepirudin is indicated for anticoagulation in patients with heparin-induced thrombocytopenia (HIT). We describe 2 cases of HIT and thrombosis in children with heart disease, including one that required extracorporeal membrane oxygenation. Lepirudin, dosed in the recommended adult weight–based fashio...

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Bibliographic Details
Published inThe Journal of pediatrics Vol. 140; no. 2; pp. 264 - 266
Main Authors Deitcher, Steven R., Topoulos, Arthur P., Bartholomew, John R., Kichuk-Chrisant, Maryanne R.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.02.2002
Elsevier
Subjects
Anticoagulants - administration & dosage
Anticoagulants - therapeutic use
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cardiomyopathy, Dilated - complications
Child
Child, Preschool
Extracorporeal Membrane Oxygenation
Female
Hematologic and hematopoietic diseases
Hirudin Therapy
Hirudins - administration & dosage
Hirudins - analogs & derivatives
Humans
Medical sciences
Pharmacology. Drug treatments
Platelet diseases and coagulopathies
Recombinant Proteins - administration & dosage
Recombinant Proteins - therapeutic use
Thrombocytopenia - chemically induced
ECMO
aPTT
HIT
Human
Thrombocytopenia
Peptides
Treatment efficiency
Hemopathy
Antiplatelet agent
Case study
Chemotherapy
Platelet
Treatment
Polypeptide
Glycosaminoglycan
Heparin
Child
Lepirudin
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Summary:Lepirudin is indicated for anticoagulation in patients with heparin-induced thrombocytopenia (HIT). We describe 2 cases of HIT and thrombosis in children with heart disease, including one that required extracorporeal membrane oxygenation. Lepirudin, dosed in the recommended adult weight–based fashion, was an effective antithrombotic agent in pediatric patients with HIT. (J Pediatr 2002;140:264-6)
ISSN:0022-3476
1097-6833
DOI:10.1067/mpd.2002.121384