Stereochemical control of tertiary alcohol: aldol condensation of lactate derivatives

Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the sta...

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Published inTetrahedron letters Vol. 42; no. 31; pp. 5249 - 5252
Main Authors Kamino, Tomoyuki, Murata, Yoshihisa, Kawai, Nobuyuki, Hosokawa, Seijiro, Kobayashi, Susumu
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 30.07.2001
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Stereoselective construction of aldol adducts having tertiary alcohol at the α position was achieved via a titanium(IV) enolate derived from a lactate derivative with an Evans chiral auxiliary. The stereochemistry at α-tertiary alcohol could be controlled by selecting the protective group of the starting lactate. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(01)00818-8