Importance of vascular endothelial growth factor (VEGF) in ovarian physiology of mammals

• Published in: Zygote (Cambridge) Vol. 21; no. 3; pp. 295 - 304
• Main Authors: Araújo, Valdevane Rocha, Duarte, Ana Beatriz Graça, Bruno, Jamily Bezerra, Pinho Lopes, Cláudio Afonso, de Figueiredo, José Ricardo
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2013
• Subjects: Animals; Cell Survival; Female; Humans; Mammals; Oocytes - physiology; Ovary - blood supply; Ovary - cytology; Ovary - physiology; Protein Structure, Tertiary; Receptors, Vascular Endothelial Growth Factor - chemistry; Receptors, Vascular Endothelial Growth Factor - metabolism; Vascular Endothelial Growth Factor A - chemistry; Vascular Endothelial Growth Factor A - physiology; Angiogenesis; Tyrosine kinase; In vitro culture; Maturation; Folliculogenesis
• ISSN: 0967-1994; 1469-8730
• DOI: 10.1017/S0967199411000578

Ovarian folliculogenesis in mammals is a complex process. Several compounds have been tested during in vitro culture of follicular cells for a better understanding of the mechanisms and factors related to ovarian folliculogenesis in mammals. From these compounds, vascular endothelial growth factor (VEGF) can be highlighted, as it is strongly associated with angiogenesis and, in recent years, its presence in ovarian cells has been investigated extensively. Previous studies have shown that the presence of VEGF protein, as well as mRNA expression of its receptor 2 (VEGFR-2) increases during follicular development. Therefore, it is likely that the interaction between VEGF and VEGFR-2 is crucial to promote follicular development. However, few studies on the influence of this factor on follicular development have been reported. This review addresses aspects related to the structural characterization and mechanism of action of VEGF and its receptors, and their biological importance in the ovary of mammals.