Cut it out: Managing hepatic abscesses in patients with chronic granulomatous disease

• Published in: Journal of pediatric surgery Vol. 38; no. 5; pp. 709 - 713
• Main Authors: Chen, Li Ern, Minkes, Robert K., Shackelford, Penelope G., Strasberg, Steven M., Kuo, Elbert Y., Langer, Jacob C.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01.05.2003; Elsevier
• Subjects: Adolescent; Adult; Biological and medical sciences; Child; Child, Preschool; Chronic granulomatous disease; Female; Granulomatous Disease, Chronic - complications; Hematologic and hematopoietic diseases; hepatic abscess; hepatic resection; Humans; Infant; Intraoperative Complications; Liver - surgery; Liver Abscess - etiology; Liver Abscess - surgery; Male; Medical sciences; Other diseases. Hematologic involvement in other diseases; Retrospective Studies; Treatment Outcome; hepatic abscess; Chronic granulomatous disease; hepatic resection; Immunopathology; Hemopathy; Immune deficiency; Genetic disease; Hepatectomy; Treatment; Surgery; Digestive diseases; Liver abscess; Leukocyte disease
• ISSN: 0022-3468; 1531-5037
• DOI: 10.1016/jpsu.2003.50189

Background: Hepatic abscesses develop in patients with chronic granulomatous disease (CGD) because the liver is a site of constant bacterial challenge. The authors investigated the roles of drainage and hepatic resection in the management of liver abscesses in CGD patients. Methods: Medical records of CGD patients with hepatic abscesses from 1990 to 2001 were reviewed. Results: There were 6 patients. Mean age of initial abscess was 7.2 years (range, 3 weeks to 18.9 years). All abscesses involved the right lobe of the liver (2 single, 4 multiple). All patients received appropriate antibiotics. Four patients were treated with one to 6 drainage procedures over one to 4 admissions before ultimately undergoing resection. The other 2 patients underwent primary resection without preliminary drainage. Of the 6 resections, 4 were nonanatomic, and 2 were anatomic. There was one major postoperative complication (bleeding) requiring reoperation. There were no recurrences after resection (mean follow-up 4.3 yr). Mean total days in hospital for the treatment of liver abscess was 49 in the preliminary drainage group and 8.5 in the primary resection group. Three patients required admission into the intensive care unit, one after a drainage procedure and 2 after resection. Conclusions: For CGD patients with hepatic abscesses, drainage procedures are associated with recurrence and prolonged hospitalization. Primary hepatic resection removing all involved tissue is safe and definitive for the management of this problem. J Pediatr Surg 38:709-713. © 2003 Elsevier Inc. All rights reserved.