Gut microbiota in obesity

• Published in: World journal of gastroenterology : WJG Vol. 27; no. 25; pp. 3837 - 3850
• Main Authors: Liu, Bing-Nan, Liu, Xiao-Tong, Liang, Zi-Han, Wang, Ji-Hui
• Format: Journal Article
• Language: English
• Published: Baishideng Publishing Group Inc 07.07.2021
• Subjects: Minireviews
• ISSN: 1007-9327; 2219-2840; 2219-2840
• DOI: 10.3748/wjg.v27.i25.3837

Obesity is a major global health problem determined by heredity and environment, and its incidence is increasing yearly. In recent years, increasing evidence linking obesity to the gut microbiota has been reported. Gut microbiota management has become a new method of obesity treatment. However, the complex interactions among genetics, environment, the gut microbiota, and obesity remain poorly understood. In this review, we summarize the characteristics of the gut microbiota in obesity, the mechanism of obesity induced by the gut microbiota, and the influence of genetic and environmental factors on the gut microbiota and obesity to provide support for understanding the complex relationship between obesity and microbiota. At the same time, the prospect of obesity research related to the gut microbiota is proposed.Obesity is a major global health problem determined by heredity and environment, and its incidence is increasing yearly. In recent years, increasing evidence linking obesity to the gut microbiota has been reported. Gut microbiota management has become a new method of obesity treatment. However, the complex interactions among genetics, environment, the gut microbiota, and obesity remain poorly understood. In this review, we summarize the characteristics of the gut microbiota in obesity, the mechanism of obesity induced by the gut microbiota, and the influence of genetic and environmental factors on the gut microbiota and obesity to provide support for understanding the complex relationship between obesity and microbiota. At the same time, the prospect of obesity research related to the gut microbiota is proposed.