The role of platelet-rich plasma in microlaryngeal surgery: a randomised, controlled trial

• Published in: Journal of laryngology and otology Vol. 136; no. 8; pp. 737 - 741
• Main Authors: Gaafar, A, Eldeghiedy, A, ElMaghraby, R, Nouh, I, Donia, M
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2022
• Subjects: Blood platelets; Cysts; Edema; Growth factors; Main Article; Otolaryngology; Plasma; Platelets; Polyps; Regenerative medicine; Software; Standard deviation; Surgery; Symmetry; Voice Quality; Platelet-Rich Plasma; Vocal Cords
• ISSN: 0022-2151; 1748-5460
• DOI: 10.1017/S0022215121004564

Platelet-rich plasma has gained interest over the two last decades, mainly because of its role in regenerative medicine. This work aimed to assess the role of intra-operative local application of platelet-rich plasma gel in the improvement of quality of voice after microlaryngeal surgery. This was a prospective comparative study that included 40 patients undergoing microlaryngeal surgery for benign vocal fold lesions. There were two groups divided equally into study group A and control group B. The assessment of voice was performed by videostroboscopy and acoustic analysis pre-operatively and at two weeks and one and three months post-operatively. The data demonstrated that all the stroboscopic and acoustic parameters showed significant improvement in both groups. Group A showed significant improvement regarding acoustic parameters at the third post-operative follow up when compared with group B. Platelet-rich plasma has a beneficial effect on voice quality following microlaryngeal surgery based in particular on acoustic parameters.