Effects of starvation and refeeding on growth performance, appetite, growth hormone–insulin-like growth factor axis levels and digestive function of Acipenser dabryanus

• Published in: British journal of nutrition Vol. 126; no. 5; pp. 695 - 707
• Main Authors: Wu, Xiao-yun, Chen, Ye-yu, Lai, Jian-sheng, Liu, Ya, Song, Ming-jiang, Gong, Quan, Long, Zhi-hai
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.09.2021
• Subjects: Acipenser dabryanus; Amino acids; Animal Nutritional Physiological Phenomena; Animals; Appetite; Biochemistry; Body composition; Body Weight; Body weight gain; Catfish; Compensation; Composition; Digestion; Enzymatic activity; Enzymes; Fasting; Feed conversion; Feed efficiency; Fishes - growth & development; Fishes - physiology; Fishing; Food; Food supply; Growth factors; Growth Hormone; Growth hormones; Growth rate; Insulin; Insulin-like growth factor I; Insulin-Like Growth Factor I - genetics; Insulin-like growth factors; Intestine; Lipids; mRNA; Muscles; Neuropeptide Y; Nutritional Endocrinology; Performance indices; Physiological effects; Physiology; Proteins; RNA, Messenger; Starvation; Sturgeon; Appetite; Acipenser dabryanus; Compensatory growth; Growth hormone–insulin-like growth factors
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1017/S0007114520004389

The aim of this study was to explore the effects and mechanisms of different starvation treatments on the compensatory growth of Acipenser dabryanus. A total of 120 fish (60·532 (sem 0·284) g) were randomly assigned to four groups (fasting 0, 3, 7 or 14 d and then refed for 14 d). During fasting, middle body weight decreased significantly with prolonged starvation. The whole-body and muscle composition, serum biochemical indexes, visceral indexes and digestive enzyme activities had been effected with varying degrees of changes. The growth hormone (GH) level in serum was significantly increased in 14D; however, insulin-like growth factor-1 (IGF-1) showed the opposite trend. The neuropeptide Y (npy) mRNA level in brain was significantly improved in 7D; peptide YY (pyy) mRNA level in intestine was significantly decreased during fasting. After refeeding, the final body weight, percentage weight gain, specific growth rate, feed intake, feed efficiency and protein efficiency ratio showed no difference between 0D and 3D. The changes of whole-body and muscle composition, serum biochemical indexes, visceral indexes and digestive enzyme activities had taken place in varying degrees. GH levels in 3D and 7D were significantly higher than those in the 0D; the IGF-1 content decreased significantly during refeeding. There was no significant difference in npy and pyy mRNA levels. These results indicated that short-term fasting followed by refeeding resulted in full compensation and the physiological and biochemical effects on A. dabryanus were the lowest after 3 d of starvation and 14 d of refeeding. Additionally, compensation in A. dabryanus may be mediated by appetite genes and GH, and the degree of compensation is also affected by the duration of starvation.