Total synthesis of haliclamine A, a macrocyclic marine alkaloid related to the key biogenetic intermediate of manzamines
The first total synthesis of haliclamine A ( 1), a macrocyclic marine alkaloid closely related to the key bisdihydropyridine intermediate 3 of the biogenetically unique manzamine family, has been efficiently achieved via stepwise inter- and intramolecular N-alkylations of 3-alkylpyridine derivatives...
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Published in | Tetrahedron letters Vol. 38; no. 52; pp. 8981 - 8984 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
29.12.1997
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The first total synthesis of haliclamine A (
1), a macrocyclic marine alkaloid closely related to the key bisdihydropyridine intermediate
3 of the biogenetically unique manzamine family, has been efficiently achieved via stepwise inter- and intramolecular
N-alkylations of 3-alkylpyridine derivatives
26 and
28.
The first convergent total synthesis of biogenetically stimulating haliclamine A (
1) has been efficiently accomplished via inter- and intramolecular
N-alkylations of 3-alkylpyridine derivatives. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(97)10368-9 |